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-**KEY POINTS**
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**Question.** Among adult hospitalizations in a national claims database, does a deep learning model using ICD-10-CM diagnosis codes improve prediction of 30-day unplanned readmission and 30-day postdischarge in-hospital mortality compared with benchmark models based on Charlson and Elixhauser comorbidity indices?
**Findings.** In this cohort study of 3,226,831 temporally held-out discharges, the ICD-10-CM--based model showed better discrimination than benchmark comorbidity-index models for both outcomes.
**Meaning.** Using the full set of discharge diagnosis codes may improve short-term claims-based outcome prediction beyond summary comorbidity indices.
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## Introduction (Background and Significance)